Radiotherapy-induced Gadd45a impairs lacrimal gland epithelial cell migration and proliferation

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Radiotherapy‑induced Gadd45a impairs lacrimal gland epithelial cell migration and proliferation.

Radiotherapy‑induced lacrimal gland injury is a serious clinical problem currently lacking satisfactory therapeutic strategies. Exploring the mechanisms underlying secondary injuries caused by radiation may aid in the development of novel targeted medicine. In the current study, growth arrest and DNA damage‑inducible 45 α (Gadd45a), a gene which is upregulated in irradiated skin, was observed a...

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ژورنال

عنوان ژورنال: Molecular Medicine Reports

سال: 2013

ISSN: 1791-2997,1791-3004

DOI: 10.3892/mmr.2013.1636